Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials. Which is better for summer heat? In 2016, the US Food and Drug Administration (FDA) required manufacturers to display potassium content of foods on the Nutrition Facts food label (48). The presence of potassium is also required for the activity of pyruvate kinase, an important enzyme in carbohydrate metabolism (5). National Library of Medicine 2017;28(5):1577-1585. Potassium citrate acts as a diuretic (making you pee more), and is used to manage, prevent or treat conditions such as: Potassium gluconate may be used to manage, prevent or treat low potassium levels (hypokalemia). 23. 2012. 2013 Aug 15;305(4):F592-9. The information should not be used in place of a consultation with a competent health care or nutrition professional. Potassium chloride or potassium citrate? Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Neither should be taken until a medical evaluation and blood tests have been completed. Another three-month, randomized, placebo-controlled trial in 244 adults (50 years) examined the effect of oral potassium bicarbonate, at either 39 mg/kg/day or 58.5 mg/kg/day, on markers of bone turnover (29). signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. What is the difference between potassium gluconate and chloride and which is better to take as an OTC supplement if one has repeated low potassium levels? J Physiol. Potassium is a mineral that is found in many foods and is needed for several functions of your body, especially the beating of your heart. Bhojani N, Bjazevic J, Wallace B, Lee L, Kaler KS, Dion M, Cowan A, Sultan N, Chew BH, Razvi H. Can Urol Assoc J. Moreover, avoid these supplements if you: Interaction with alcohol is unknown, thus, stay on the safe side and avoid alcoholic beverages while using these supplements. Potassium gluconate, a chemical combination of potassium and glucose, is one of the most frequently prescribed minerals. In the absence of treatment, hypokalemia can have serious complications and even be fatal (see Deficiency). HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Endocrinol Metab Clin North Am. The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. J Am Heart Assoc. Outdated tetracycline antibiotics have been linked to electrolyte disturbances. Trinchieri A, Zanetti G, Curro A, Lizzano R. Effect of potential renal acid load of foods on calcium metabolism of renal calcium stone formers. Eating a diet with enough potassium can help prevent diseases and conditions, such as stroke, hypertension, osteoporosis and kidney stones, according to the Linus Pauling Institute. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Your doctor may prescribe potassium citrate if you have a mild urinary tract infection, such as cystitis. Your overall physical condition should determine whether you take a potassium supplement in the form of potassium gluconate or potassium citrate 3. What Is the Difference Between Magnesium Glycinate and Magnesium Gluconate? Your doctor may change the dose if needed. Therefore, here is a complete list of foods rich in potassium: flax seeds, pistachios, beet greens, raisins, almonds, oat bran, dates, white beans, lima beans, spinach, soybeans, chia seeds, avocado, sweet potatoes, potatoes, kiwi, prunes,lentils, bananas, broccoli, onion, chickpeas, cantaloupe, winter squash, celery, apricots,orange, mango,radish, tomatoes, millet, strawberries, pineapples, pear, and apples. In rare cases, habitual consumption of large amounts of black licorice has resulted in hypokalemia (7, 8). Dietary potassium supplements typically contain potassium chloride. Corvallis, Oregon 97331, phone: 541-737-5075 | fax: 541-737-5077 National Institutes of Health, Health Claim Notification for Potassium Containing Foods. 1993;123(9):1623-1626. Several medications, including aminoglycosides, anti-fungal agents (amphotericin-B, fluconazole), and cisplatin, can damage the renal tubular epithelium and lead to severe potassium loss. The alkaline characteristics may help in those with metabolic acidosis, or in those susceptible to kidney stones. Portions of this document last updated: April 01, 2023. The effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. N Engl J Med. Chronic hypokalemia is associated with hypertension and kidney stone formation (see Disease Prevention and Disease Treatment). Before J Am Coll Cardiol 2011;57:1210-9. Potassium chloride is a form of potassium for people who delivers a much larger dose but has problems with gastrointestinal side effects. Some relatively good dietary sources of potassium are listed in the Table 2, along with their potassium content in milligrams (mg). Dietary Reference Intakes for Sodium and Potassium - uncorrected proofs. Electrolyte imbalance (high or low sodium, chloride, or carbon dioxide in the blood) or Heart disease or Kidney diseaseUse with caution. However, potassium gluconate contains less elemental potassium than potassium chloride. Hypokalemia. 48. Because fruit and vegetables are rich in both potassium and precursors to bicarbonate ions, increasing their consumption might help reduce the net acid content of the diet and preserve calcium in bones, which might otherwise be mobilized to maintain normal pH (see the article on Fruit and Vegetables). Because of the potential for serious side effects, one should seek medical advice before deciding to use a potassium supplement (see Safety ). UPDATE - Canadian Urological Association guideline: Evaluation and medical management of kidney stones. Clausen T. Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance. Taking Gabapentin With Lipitor - Pharmacist Analysis. Potassium Supplements Review. J Am Soc Hypertens. Both potassium citrate and potassium gluconate may be used as food additives or supplements, but they have some slightly different applications. In last lab test, my Potassium dropped from 4.1 MEq to 3.1. Jackson SL, Cogswell ME, Zhao L, et al. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Fact Sheet for Consumers. Potassium citrate is a urinary alkalinizer. However, most people will not take more than 100 mEq a day. Citrate uses a differnt salt. Injectable potassium is administered only by or under the supervision of your doctor. What's more appropriate for hypokalemia or hypokalemic periodic paralysis? Yong Sun, et al. Circulation. 2013;98(1):207-217. WebThe effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. Potassium citrate may be added to foods to enhance flavor, add potassium or regulate acidity. Trans Assoc Am Physicians. Difference of meds: Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. Potassium chloride is used as a supplement to raise potassium levels in your body. Please explain. Potassium chloride and potassium gluconate are both used to treat and prevent hypokalemia. In contrast, a two-year randomized controlled trial found that neither supplementation with potassium citrate (721 mg/day or 2,165 mg/day) nor an increase in fruit and vegetable intake (300 mg/day) had an impact on markers of bone turnover or increased BMD in postmenopausal women (30). Curhan GC, Willett WC, Speizer FE, Spiegelman D, Stampfer MJ. Drug information provided by: Merative, Micromedex. Nutrients. (PubMed). (PubMed), 42. (PubMed), 46. Your doctor may change the dose if needed. It maintains proper muscle and nerve function, is involved in metabolic processes, and helps control blood pressure. (PubMed), 16. According to the Academy of Nutrition and Dietetics, the recommended daily intake of this mineral is 4,700 milligrams, however, most people in the United States consume barely half that amount. The most common strengths are: Eachmilliequivalent of potassium chloride contains 75 mg. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Your doctor may change the dose if needed. A clinical trial of the effects of dietary patterns on blood pressure. Advertising revenue supports our not-for-profit mission. Binia A, Jaeger J, Hu Y, Singh A, Zimmermann D. Daily potassium intake and sodium-to-potassium ratio in the reduction of blood pressure: a meta-analysis of randomized controlled trials. If you are on a salt (sodium)-restricted diet, check with your doctor before using tomato juice to dilute your medicine. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Clipboard, Search History, and several other advanced features are temporarily unavailable. Theyre also not available in the same dosage forms. Thanks for your question! National Institutes of Health, Lambert H, Frassetto L, Moore JB, et al. Stone M, Martyn L, and Weaver C. Potassium intake, bioavailability, hypertension, and glucose control. Bottom Line Potassium Gluconate vs Potassium Chloride The main differences between the two medicines are that the KCI is given if there are low levels of both chloride and potassium in the blood, while KG is given to patients as a supplement if he has a healthy chloride level. It can sometimes be difficult to understand the difference in potassium products, as we are dealing with different units of measure (mEq vs. mg) and different salt forms (chloride vs. gluconate). 2013;23(3):223-227. Purdue University, Copyright 2001-2023 Linus Pauling Institute. Weaver CM. Am J Med. Nancy Williams has been writing about health-related topics since 1979. Pak CY, Fuller C, Sakhaee K, Preminger GM, Britton F. J Urol. The activation of Na+/K+-ATPase requires the presence of sodium and potassium. Southwestern Internal Medicine Conference: medical management of nephrolithiasis--a new, simplified approach for general practice. Increasing dietary potassium (and alkali) intake by increasing fruit and vegetable intake or by taking potassium bicarbonate (KHCO3) supplements has been found to decrease urinary calcium excretion. Potassium chloride or potassium citrate? The revised AI values are 2.6 g/day for women and 3.4g/day for men (see The Adequate Intake). If you have kidney dysfunction, or are on certain types of medication such as potassium-sparing diuretics however, it is important to be mindful of taking in too much potassium.. 2017;2(19):e94920. Potassium chloride supplementation averted thiazide-induced hypokalemia and hypocitraturia without influencing hypocalciuric action of thiazide or urinary pH. There is no evidence that potassium supplements are useful in the treatment of high blood pressure. Epub 2018 Nov 26. Potassium is the 3rd most abundant mineral in the human body and is vital for the maintenance of acid-base balance as well as for the maintenance of normal whole-body and cellular fluid levels. 1995;268(4 Pt 2):R825-837. WebPotassium Citrate and Potassium Gluconate Versus Potassium Chloride: Experimental Evaluation of Relative Intestinal Toxicity | JAMA | JAMA Network IN LATE 1964 a sudden increase in the occurrence of circumferential ulcerating, stenosing lesions of the small bowel was noted both in Europe and the United Sta [Skip to Navigation] Increased potassium intake resulted in overall reductions of systolic blood pressure by 4.7 mm Hg and diastolic blood pressure by 3.5 mm Hg. Among other differences, the daily intake of sodium chloride (salt) in modern diets is about three times higher than the daily intake of potassium on a molar basis, whereas salt intake in primitive cultures is about seven times lower than potassium intake (13). Potassium gives you energy. Lancet. Chronic hypertension damages the heart, blood vessels, and kidneys, thereby increasing the risk of heart disease and stroke, as well as hypertensive kidney disease (34, 35). Food and Nutrition Board, National Academy of Medicine. N Engl J Med. Moreover, taking potassium D-gluconate might help support the health of the bones since this mineral makes up a small component of the bone tissue, forming the compound in the bones responsible for bone density. Both potassium supp: Citrate acts as a buffer/alkali in conditions with high acid (acidemia). Morris RC, Jr., Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. The use of more potent potassium supplements in potassium deficiency requires close monitoring of serum potassium concentrations. Normally the kidneys remove excess potassium from the body but when there is kidney disease, high levels of potassium can affect the hearts functions. If you have kidney disease, gout or kidney stones, potassium citrate is preferred because of its chemical composition 3. Potassium plays an important role in maintaining the health of your kidneys, heart, muscles, and nervous system. N Engl J Med 1993;328:833-8. He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Your doctor may change the dose if needed. In conclusion, potassium citrate supplementation may be superior to potassium chloride supplementation in patients receiving thiazide in whom stones form. Therefore: Now, even though we have the total milligram quantity of potassium chloride, we need to do a further conversion to find out how much elementalpotassium is contained within potassium chloride. Imran Dosani answered. Bookshelf Our team periodically reviews articles in order to ensure content quality. The solution should be well mixed into water or juice. Food and Nutrition Board, National Academy of Medicine. Sanghavi S, Vassalotti JA. In: Stipanuk M, ed. 23 years experience. Answered by Dr. Brian Staiger, PharmD From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Connect with a U.S. board-certified doctor by text or video anytime, anywhere. So is it correct and ok to do this? However, most people will not take more than 100 mEq a day. Your doctor may change the dose if needed. Experimental evaluation of relative intestinal toxicity. She is working on a book about historic sites in the West. 8600 Rockville Pike Potassium charges the cells - that voltage from potassium powers your cells and allows things to go in and out of the cells. Ann Intern Med 1997;126:497-504. I've been treated for multiple myeloma for 10 years. Formerly used in: Qualitative cation tests. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Forty-five percent of US adults have hypertension (blood pressure levels 130/80 mm Hg) (33). Do not crush or chew the capsule. The richest sources of potassium are fruit and vegetables. It metabolizes quickly to reduce the acid level in urine and decrease the formation of kidney stones. The usual dose is 2 to 3 mEq per kilogram (kg) (0.9 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. JAMA. For oral dosage form (powder for suspension): Adults and teenagers20 mEq dissolved in two to six ounces of cold water, taken one to five times a day. Please considermaking a giftto the Micronutrient Information Center today. email:[emailprotected], Chlorophyll and Metallo-Chlorophyll Derivatives, Healthcare Professional Continuing Education, 2015-2020 Dietary Guidelines for Americans, https://www.cdc.gov/bloodpressure/facts.htm, Potassium Intake of the US Population: What We Eat In America, NHANES 2009-2010, https://www.regulations.gov/document?D=FDA-2012-N-1210-0875, https://naturalmedicines.therapeuticresearch.com, Angiotensin converting enzyme (ACE) inhibitors, captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), ramipril (Altace), Losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), candesartan (Atacand), Trimethoprim-sulfamethoxazole, pentamidine, Nonsteroidal anti-inflammatory agents (NSAID), spironolactone (Aldactone), triamterene (Dyrenium), amiloride (Midamor), amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), tobramycin (Nebcyn), streptomycin, amphotericin B (Abelcet, Amphotec, AmBisome, Amphocin, Fungizone), fluconazole (Diflucan), albuterol (Salbutamol, Ventolin), bitolterol (Tornalate), metaproterenol (Alupent), methylxanthines (e.g., theophylline), sodium polystyrene sulfonate, sodium phosphates, caffeine, Potassium is considered to be a "nutrient of public health concern" according to the 2015-2020 Dietary Guidelines for Americans since its underconsumption in the US population is associated with adverse health effects (. Victoria J. Drake, Ph.D. Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. In: Burckhardt P, Dawson-Hughes B, Heaney R, eds. However, most people will not take more than 100 mEq a day. A 2014 meta-analysis of 17 randomized controlled trials that examined the effect of the DASH diet compared to a control diet in a total of 2,561 adults found overall reductions in systolic and diastolic blood pressure by 6.7 mm Hg and 3.5 mm Hg, respectively (39). PMC Other differences between the two include: Converting Potassium Chloride To Potassium Gluconate. Jane Higdon, Ph.D. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. Its formula is: c6h11ko7. Is NyQuil (Or DayQuil) Safe To Take With Paxlovid? Potassium causes calcium retention in healthy adults. Each replenishes the bodys potassium but the type you should use is determined by underlying physical conditions. What are the differences between potassium chloride ER 20 mEq and Nature Made Potassium Gluconate 550 mg? Thirteen studies included hypertensive participants who were not taking anti-hypertensive medication and two studies included normotensive or at-risk subjects. Long-term treatment of calcium nephrolithiasis with potassium citrate. It is important to discuss your options with your doctor as there are a variety of factors that need to be taken into consideration in regards to regaining normal potassium levels. Gitelmans (GS) and Bartters (BS) syndromes are rare, inherited autosomal recessive tubulopathies characterized by hypokalemia, metabolic alkalosis, renal sodium, chloride, and potassium and magnesium-wasting. Licorice-induced hypertension and syndromes of apparent mineralocorticoid excess. However, most people will not take more than 100 mEq a day. The usual dose is 2 to 3 mEq per kg (0.9 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. Your doctor may change the dose if needed. Review/update the the unsubscribe link in the e-mail. Hyperkalemia may also result from a shift of intracellular potassium into the circulation, which may occur with the rupture of red blood cells (hemolysis) or tissue damage (e.g., trauma or severe burns). The symptoms of hypokalemia are related to alterations in membrane potential and cellular metabolism (1). Potassium salt can be bought from a number of retailers including Amazon, Walmart, and Instacart. (PubMed), 21. information submitted for this request. J Nutr. 2019 Feb;47(1):107-113. doi: 10.1007/s00240-018-1090-6. 22. Arch Ital Urol Androl. Mumoli N, Cei M. Licorice-induced hypokalemia. The Dietary Approaches to Stop Hypertension (DASH) trial provided evidence of the blood pressure-lowering effect of a diet higher in potassium and calcium, modestly higher in protein, and lower in total fat, saturated fat, cholesterol, red meat, sweets, and sugar-containing beverages compared to the typical US diet (38). Linus Pauling Institute WebDr. Acute or chronic kidney failure, the use of potassium-sparing diuretics, and insufficient aldosterone secretion (hypoaldosteronism) may result in the accumulation of potassium due to a decreased urinary potassium excretion. // Leaf Group Lifestyle. We comply with the HONcode standard for trustworthy health information. Increasing potassium intake to recommended levels (see Adequate Intake) by consuming a diet rich in fruit and vegetables can help lower blood pressure and may have additional benefits to health (see the article on Fruit and Vegetables). I was tasked with comparing Advair, Breo and Trelegy. Please enable it to take advantage of the complete set of features! government site. Follow your doctor's orders or the directions on the label. Yet, although reducing sodium consumption while increasing potassium intake helps with lowering blood pressure (45), current evidence suggests that dietary advice and support interventions may not be sufficient to deliver long-term cardiovascular benefits in individuals with hypertension (46). Ice cream lab. Get answers from Nephrologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. (PubMed), 24. Association between urinary sodium and potassium excretion and blood pressure among adults in the United States: National Health and Nutrition Examination Survey, 2014. Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. 2010;4(2):79-89. For potential or actual medical emergencies, immediately call 911 or your local emergency service. The solution should be well mixed in water or juice. Potassium's cardiovascular protective mechanisms. WebWhat is the difference in potassium gluconate, chloride, citrate? The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. A two-year randomized, double-blind, controlled trial in 201 older adults without osteoporosis (mean age, 69 years) found evidence of increased lumbar spine, hip, femoral neck, and total-body BMD, as well as trabecular BMD of the radius and tibia, with supplemental potassium citrate (2,340 mg/day) compared to placebo (28). Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. WebPotassium citrate and potassium gluconate versus potassium chloride. 2016;5(10). 2013;4(3):368s-377s. (PubMed), 18. Poorolajal J, Zeraati F, Soltanian AR, Sheikh V, Hooshmand E, Maleki A. (PubMed), 3. Potassium chloride is a form of potassium for people who have low levels of potassium which is the preferred form to use on a ketogenic diet. Medical Content Reviewed By HelloPharmacist Potassium Chloride contains more elemental potassium than potassium gluconate. However, insufficient dietary potassium in patients at risk of hypokalemia can precipitate hypokalemia (1). Careers. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. 11 Researchers found that compared to those with higher potassium levels (4.5mmol/L), those with lower levels (<4.0mmol/L) had significantly higher fasting glucose. Dr. Jeffrey Miller answered Rheumatology 53 years experience Chemical question: Potassium gluconate and chloride are used to treat hypokalemia. (PubMed), 41. Abnormally high urinary calcium (hypercalciuria) increases the risk of developing kidney stones. Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. K-TAB tablets are an electrolyte replenisher. Water, electrolytes, and acidBase Metabolism In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Distinguished Professor and Department Head Mandal AK. Accessed 11/19/18. Larsen BR, Stoica A, MacAulay N. Managing brain extracellular K(+) during neuronal activity: the physiological role of the Na(+)/K(+)-ATPase subunit isoforms. 2016;388(10043):465-475. It is used to treat a kidney stone 5. I'm confused about the difference between all the different types of Mucinex products out there. Adv Nutr. Finally, many salt substitutes contain potassium chloride, and acesulfame potassium (Ace-K) is an FDA-approved general purpose sweetener. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Our body regulates potassium concentrations to achieve a certain level both inside and outside the cell but, for variety of reasons, that concentration can either go too high (hyperkalemia) or too low (hypokalemia). In addition to the potassium loss created by these medications, chloride is often also lost from the body in significant amounts. Experimental evaluation of relative intestinal toxicity. Weaver CM. Indeed, compared to the control diet providing only 3.5 servings/day of fruit and vegetables and 1,700 mg/day of potassium, adherence to the DASH diet that included 8.5 servings/day of fruit and vegetables and 4,100 mg/day of potassium lowered systolic/diastolic blood pressures by an average 11.4/5.5 mm Hg in people with hypertension and 3.5/2.1 mm Hg in those without hypertension (38). Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Potassium is a normal component of a regular, well rounded diet and is contained in many foods such as meats, fruits and vegetables. Washington, D.C.: The National Academies Press; 2019. 1997;81(3):611-639. Potassium/Professional Monograph/Interactions with Drugs. Overall, whether consuming potassium-rich fruit and vegetables can influence bone health and help lower the risk of osteoporosis remains uncertain (see also the article on Fruit and Vegetables). Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. WebPotassium Chloride Freezing point depression. It is used when your urine is too acidic. doi: 10.1152/ajprenal.00116.2013. WebPOTASSIUM GLUCONATE (poe TASS i um GLOO koe nate) prevents and treats low levels of potassium in your body. WebDietary source Of the major minerals, magnesium ranks sixth (Ca 2+ > P > K + > Na + > Cl-> Mg 2+) in overall abundance in the body. Potassium citrate is a chemical combination of potassium and citric acid and is one of the most absorbable forms of the mineral 3. privacy practices. 2022 Jun;16(6):175-188. doi: 10.5489/cuaj.7872. Nutr Metab Cardiovasc Dis. ONeil C, Keast D, Fulgoni V, and Nicklas T. Food sources of energy and nutrients among adults in the US: NHANES 2003-2006. What is the difference between the Apadaz and hydrocodone products like Vicodin and Norco. 47. Cogswell ME, Loria CM, Terry AL, et al. However, most people will not take more than 100 mEq a day. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. 26. Mayo Clinic does not endorse companies or products. Many thanks for your help. To provide you with the most relevant and helpful information, and understand which We found that KCl supplementation for 4 weeks induced a significant reduction in nighttime SBP compared with placebo (116 12 vs 121 15 mm Hg, respectively, p <0.01 vs placebo), whereas KMgCit and KCit had no significant effect in the same subjects (118 11 and 119 13 mm Hg, respectively, p >0.1 vs placebo). Weaver CM, Stone MS, Lobene AJ, Cladis DP, Hodges JK. An abnormally low plasma potassium concentration is referred to as hypokalemia. Copyright: Merative US L.P. 1973, 2023. Hsi RS, Yan PL, Crivelli JJ, Goldfarb DS, Shahinian V, Hollingsworth JM. ChildrenDose is based on body weight and must be determined by your doctor. Observational studies have consistently reported an increased risk of cardiovascular disease with elevated dietary sodium intakes (14, 15).