Crusted scabies does not usually cause a rash or itching, but can cause red patches and scaly plaques on the skin. The recent development of a porcine model for human scabies [51] holds significant potential as a tool for scabies drug development, as pigs develop similar clinical responses to S. scabiei infestation and have similar skin physiology. A subreddit related to scabies and treatments. Scabies Means Misery. My wife and kids are scabies free without much effort. I found myself refilling my perscription 7 days later and reapplying it because even the package says it may need second dosage 7 days later. No, Is the Subject Area "Mites" applicable to this article? Be aware moxidectin and ivermectin have been approved by the FDA in humans but only for treating a disease called river blindness. At this point I went to a community urgent care. i am so scared that it didnt go away but i am trying to have faith. Looking at the prospects for scabies drug development, the target product profile for any new drug must be considered carefully. PLoS Negl Trop Dis 10(3): You can even mix it with a little applesauce or strawberry jam to make it more palatable. The simplest way to measure a small dose is to measure out a DOUBLE dose using the numbers on the syringes plunger and then squirt that amount onto a plate. Forum: Parasites Support Forum (Alt Med) . These issues with topical treatment adherence meant that the addition of oral ivermectin to the scabies arsenal in the mid-1990s was greeted with optimism [].Twenty years later, uptake of ivermectin for scabies has been relatively slow, with the primary indication being for institutional scabies outbreaks and for the treatment of severe crusted scabies, for which . Match. Flashcards. http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002387#pntd.0002387-Huffam1. The day TWO application is for the lotion to take care of those that are under the skin. 100 users are following. My body is itching and I feel scabies biting me on thighs, my arms, back, legs and stomach. Indeed, under the underutilised FDA Animal Rule[50], animal surrogates may be deemed acceptable when human challenge studies are not ethical or feasible. and our This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. A 1% topical ivermectin treatment was also recently approved by the US Food and Drug Administration (FDA) for the treatment of rosacea (presumably with activity against Demodex mites) [25,26], which is not explicitly contraindicated in pregnancy or breastfeeding, but rather, treatment may be warranted if benefits to the mother are perceived to outweigh the risk [27]. I search for good deals on good products for myself and tell you where to find them. Study record managers: refer to the Data Element Definitions if submitting registration or results information. For the treatment of ordinary scabies, it is only licenced in a few countries; in Australia and New Zealand, it is only registered as a second-line treatment where failure with topical creams has been observed, and in France, it is used as a single administration [16]. Always speak to your doctor before acting and in cases of emergency seek A single dose of moxidectin cures scabies better than two doses of ivermectin (a week apart). Talk with your doctor and family members or friends about deciding to join a study. So relax. The second dose still didnt kill or cure all. Each subject will receive the same number of tablets made up of moxidectin 2 mg tablets and placebo tablets to maintain the blind. DO NOT take both ivermectin and moxidectin at the same time. Known or suspected hypersensitivity to macrocyclic lactones or excipients used in the formulation of moxidectin. Cookie Notice After taking taking ivermectin it takes about a week for it to exit the body, then one could use moxidectin. Before Using. With ivermectin one takes one or two doses a week, but not with moxidectin! In a clinical study humans were given doses of moxidectin from 3 mg to 36 mg, up to ~0.6 mg/kg. mites(bigger nymphs) or teen mites (even bigger nymphs). Yes So even though repeated weekly doses of ivermectin can kill scabies mites, moxidectin persists for the entire life cycle of the mites and beyond. The introduction of the macrolide agents ivermectin (Heartgard R), milbemycin oxime (Interceptor R), moxidectin (ProHeart R and ProHeart R 6) and selamectin (Revolution TM) has provided the veterinary profession with effective heartworm (HW) preventatives in a variety of formulations.Such agents, because they interrupt larval development during the first 2 months after infection . As a subscriber, you have 10 gift articles to give each month. Order Zanaflex Online Usa; Tizanidine Generic Pills Purchase; Where To Buy Online Zanaflex Stockholm; Zanaflex Cheap No Prescription; Buy Female Zanaflex Online Cheap Use of the forums is subject to our Terms of Use While permethrin treatment is relatively straightforward (apply the cream from head to toe, leave for at least 8 hours, and rinse off), this is impractical for community mass drug administration (MDA), and indeed, recent studies show limited sustainability of interventions in which treatment was not directly observed [12]. Maybe someone else has more info on this too. Because moxidectin stays in the body a long time it means one dose of moxidectin is enough to treat scabies. Let your provider know if you notice any swelling anywhere in your body, since you might need to be . respect of any healthcare matters. Histamine is one of your immune systems ways of fighting against an allergen such as the Scabies. They do recommend that once you have such a plethora of scabies, i.e. After that night of basically no sleep and in the bath, I went on webMD and typed in all my symptoms and it came up with scabies as one of the possibilities, especially with the itching and scratching at night. And if you think about it, it make sense that they are suvivors, they have been around for a long long time. Moxidectin (MOX), with more advantageous pharmacological profiles may be a promising alternative. 2.Mixture of isopropryl alcohol w/ vinegar (50/50). It took a month or two to really stop seeing new bumps form, but I heard it could take a while for all the scabies that died due to ivermectin to come out of skin, and while they are there still they show symptoms of iratation, i.e. Previous enrolment and treatment with moxidectin in this study. Dab a sticky tape on the speck & it'll stick to the tape. Chlorine seems to irritate them & kill them or leave me. . In the future, moxidectin may be a suitable treatment for scabies (e39, e40). When higher concentrations (1 mg/kg) of a long-acting formulation were used, 100% efficacy was achieved in a single dose [41]. I still feel like something is crawling under my skin and in my hair. Although millions of doses have been administered for onchocerciasis, with few well-documented serious adverse effects outside Loa loa-endemic areas, there remain concerns regarding its safety in children weighing less than 15 kg and in pregnancy and breastfeeding, although no increased risk has been found in cases of inadvertent exposure in these groups [20,21]. Pinch the skin together at the area of interest and scrape the skin firmly to . Clinical features Scabies is highly contagious and there may be a history of contact with other dogs, [] and Privacy Policy and steps will be taken to remove posts identified For more information, please see our Significantly less bites. Scabies mites cause disease in other species as well, and the World Health Organization (WHO) includes scabies, . Scabies are typically diagnosed through skin scrapings that are examined under a microscope. Combines 2% moxidectin and 12.5% praziquantel for the treatment and control of large and small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large mouth stomach worms, stomach bots and tapeworms. In one study, considerable variation in skin ivermectin concentration was reported and related to sebum levels. Ivermectin is available at relatively low cost or has been provided free or heavily subsidized by manufacturers for use in large control programmes. I made sure that to throw these away every time I touched something I thought could possibly have been contaminated. My husband seem to be greatly improved but I go briefly better and then worse. Afterwards towel drying myself, I re-apply the toothpaste and cellulos tape, 7.Get Claratyne or Zyrtec (or any other Antihistamine) so that you dont get itchy. With increasing recognition of scabies as a global health problem, improved control of scabies in endemic communities is achievable, pending support from donors and funding agencies and the availability of new treatments that are more amenable for use in MDA. And buy like two of three of these for the day. Approximately around two weeks ago, after weeks of persistent itching and long research I confirmed I had scabies despite the doctors dismissing it as eczema. A live mite was found on a skin scraping on one of these dogs 28 days after the . The tube comes with a dial you'll turn with notches for your weight. Moxidectin is an anthelmintic indicated for the treatment of onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older. Known or suspected alcohol or illicit substance abuse. Methodology/principal findings: Using a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0.3 mg/kg once), IVM (0.2 mg/kg twice) or no treatment. When it comes to scabies, this factor could be a game changerif the drug is retained at therapeutic concentrations in the skin through the 14-day scabies life cycle, a single-dose regimen may be possible. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Product Manufactured in and Exported from the U.S.: Death of adult scabies mites [TimeFrame:28 days], Incidence of adverse events [TimeFrame:12 weeks], Severity of adverse events [TimeFrame:12 weeks], Analysis of moxidectin plasma concentrations [TimeFrame:28 days], Incidence and severity of scabies signs and symptoms [TimeFrame:28 days], Severity of pruritus [TimeFrame:28 days]. Moxidectin is well established in veterinary practice to treat a range of parasites, including sarcoptic mange. All over your body, that you combine applying Permethrin "5%" with the oral Vermectin dose on the same day. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. Some are very short, 1/8th inch up to nice long ones. Diagnosis of crusted/Norwegian scabies or scabies that, in the opinion of the Investigator, would require treatment with more than one standard of care (e.g. Presence of any other clinically relevant condition, including infection, immunological disorder, malignant disease, and/or other underlying condition or circumstance at Screening or Baseline that would put the subject at increased risk from participating in the study or confound study evaluations. Moxidectin was associated with transient CNS-related clinical signs. I have literally read ever scientific article published in the last 20 years about scabies and finally stumbled on info about moxidectin. Its from the olden days & it burns), 5c.Salt bath (minimal results). I bought plastic pillow cover from Wal-Mart I think. First of all, a huge thank you to this community for educating me on Moxidectin and the MaxImpulse site. I would say it's your best bet and being cured. Needless to say they were very unhelpful, one of the nurses told me that simple lice shampoo would take care of the problem. So I took her advice and went to Rite Aid and bought some and put in all over my body. The red line shows that 5 days after taking ivermectin almost all of the ivermectin is gone from the body. The consequence of this is that ivermectin monotherapy is not recommended for cases of crusted scabies, with concomitant therapy with a topical acaricide such as permethrin and keratolytic supplementation required [30]. dermatitis. appropriate medical assistance immediately. Learn. One report says, . Preliminary studies in a porcine model of scabies are encouraging in this respect, with a single 0.3 mg/kg dose of moxidectin achieving high clinical efficacy with prolonged retention in skin [44]. If successful, this would facilitate its development for scabies and other indications for which a long-acting macrocyclic lactone may be more effective than ivermectin. I have been on Montelucast, 365 days a year for the last ten years, I have been off the drug since 5/29/14, it is 8/14/14 and my pock marks keep multiplying but still no regular symptoms. I really want this to work. Moxidectin is a second-generation macrocyclic lactone, related to ivermectin but with critical pharmacokinetic differences. New Medicine - Moxidectin This is a story about scabies and a new medicine called Moxidectin that we think will kill scabies mites and hatching mites from eggs laid in the burrow under the skin. When I to the Moxi I threw it up (gross) but I took it again and Im truly believing this will finally cure me, I thought I had read somewhere that taking NAC reduces moxi in your system. Dosed the two of us 23 days ago. History of chronic or recurring dermatologic disease (other than scabies) that could interfere with the diagnosis and/or subsequent clinical assessment of scabies. Moxidectin success. That is within the dosing range tested in the. Some studies show excellent efficacy as a single 0.2 mg/kg dose, with 100% cure at day 14 in cattle, In a clinical study humans were given doses of moxidectin from 3 mg to 36 mg. disposable syringes with blunt tips can be very cheap. Take the dose for your weight. Albendazole is an antiprotozoal agent with larvicidal effect, therefore it can be used as an alternative treatment of CS when oral ivermectin is unavailable, along with 5% permethrin and 5% salicylic acid. Viewpoints are opinion pieces grounded in evidence on topics of broad interest to the journal's readership. It is caused by the superficial burrowing mite Sarcoptes scabiei var canis (Figure 1). Meta-analyses [10] have shown that single-dose oral ivermectin is inferior to single-dose permethrin, meaning that two doses are required for maximal efficacy. Good luck. Then it mates, burrows under your skin and starts laying new eggs. In terms of morbidity, at 1.5 million disability-adjusted life years, scabies ranks higher than several other important NTDs, including dengue (0.83 million), onchocerciasis (0.43 million), and trypanosomiasis (0.56 million) [5]. thank you for your reply, our dermatologist said the same and asked me to stay patient and give it time. Scabies can be controlled with a pill or two, and the protective effect lasts for years, scientists reported on Wednesday. Alternative approaches, such as immunotherapy [6], vaccination [7], or directly targeting mite molecules [8], have been proposed, but given the low research base and lack of interest from pharmaceutical companies, prospects for new drug development are dim. 5,6 A member of the phylogenetic class Arachnida, scabies have a 10- to 14-day life . I noticed the bumps after they started to itch a little, but didnt think much of it. 100% real story/my story!!! I have buzz hair cut which is very short. A 2 months old female Vietnamese potbellied pig presented to a veterinary teaching hospital with a referring complaint of pruritus. At this point I was convinced I had scabies because I even talked to a doctor and he told me if the scabicide worked even a little it only works on parasites and not skin conditions such as follicleitis and others that are commonly confused with scabies. Yes To identify an optimal dose of moxidectin for the treatment of scabies. This is the tea tree oil I recommend. I bought enough to take 3 weeks in a row. 1,3,5,6. Have you heard of or tried something called Moxie short for moxidectine?? Scratching the rash may lead to impetigo, a bacterial skin infection with oozing sores. He finally went to a Derm after months of itching and not sleeping. Objectives: The study is aiming to recruit up to 30 participants in the Darwin region who have a confirmed diagnosis of scabies infection. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. canis is highly resistant [11]. Moxidectin can raise the risk of swelling, especially in the arms and legs, in people who have hyper-reactive onchodermatitis (sowda). https://patient.info/forums/discuss/cured-100-real-story-my-story--62190. It doesnt matter. Transient depression, ataxia and recumbency may be seen when very young or debilitated animals are treated. MDGH Job Listings Feb 2020. Yes The United States has no DIRECT CURE research going on, and their research into being able to competently diagnose (through scientific tests) has been only since 2007. Some studies show excellent efficacy as a single 0.2 mg/kg dose, with 100% cure at day 14 in cattle [38], whereas sheep required two 0.2 mg/kg doses to achieve cure [39,40], with a single dose reducing mites by 75%92%. For more information about PLOS Subject Areas, click Create an account to follow your favorite communities and start taking part in conversations. These issues with topical treatment adherence meant that the addition of oral ivermectin to the scabies arsenal in the mid-1990s was greeted with optimism [15]. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Use one pile as a dose and throw away the other pile. Heres an example. Scabies can be controlled with a pill or two, and the protective effect lasts for years, scientists reported on Wednesday. Vacuum. It was very hard for me to get rid of, and the post scabies rash from Moxidectin showed me I had these things all over my body in places I didnt realize. In January, infestations were detected in firefighters at two New York City firehouses, one of which had to be closed for decontamination. In poor countries, pills can be distributed throughout a village, ridding whole communities of the parasite. Current diagnostic methods for scabies are inadequate, and as such, diagnosis mostly relies on clinical presentation, which can be subjective even when well-defined clinical algorithms are employed. 5f.OliveOil & MineralOil: Effective. Each subject will receive the same number of tablets made up of moxidectin 2 mg tablets and placebo tablets to maintain the blind. THAT does not matter. Even now I feel a light new itch for a few hours. Moxi stays in your system for 16 weeks. Sorry to bother you, just wondering what your cleaning regimen was after your first dose of Moxidectin. If one also considers the complications of scabies, including bacterial skin infection, post-streptococcal glomerulonephritis, and, potentially, rheumatic fever [2], the true global health burden attributed to this tiny ectoparasitic mite is much larger [4]. Another lingering concern with ivermectin is documentation of treatment failure despite multiple doses and in vitro evidence of resistance [28]. After neem didnt work, I ordered some pure neem oil from eBay, along with coconut and olive oil. Hope this will help, if one application didn't stop the bumps, you probably have Grade one Crusted scabies. Where two doses were given, follow-up was frequent, and community visitors were continuously screened and treated, ivermectin MDA was more successful [18]. Whilst a variety of treatment and control methods have been investigated in wildlife, the literature is fragmented and lacking consensus. QUEST (moxidectin) 2% Equine Oral Gel can be safely administered at the recommended dose of 0.4 mg moxidectin/kg body weight to horses and ponies of all breeds at least 6 months of age or older. Clinical trials for assessing acaricidal agents are problematic. I would ask for multiple scrapings all over and demand ivermectin and treat topically and environmentally heavily in addition. Each gram or ml of paste is a dose for 101 lbs, so its approximately 0.1 ml per 10 pounds of body weight. in humans but only for treating a disease called river blindness. Each gram or ml of paste is a dose for 101 lbs, so its approximately 0.1 ml per 10 pounds of body weight. Agree to the use of reliable contraceptive measures if female or male partner of a female of child-bearing potential from Screening and until 6 months after treatment with study product. Absorption. It has a measuring device built into the syringes plunger (see my video on how to measure a dose COMING SOON). 5e.Lavender/Lavender spray: helps you sleep but you'll wake up when mites jump on your face or start itching somwhere on your body. Without it, Im sure I would still have scabies. Studies suggest that moxidectin is not effective for killing the adult worms; however, it inhibits intrauterine embryogenesis and release of microfilariae from the adult worms. Use of topical DDT was later linked to some cancers by the World Health Organization. Seal them in, throw away or burn it, 6.Swimming. It should be emphasised that this figure relates to the impact of scabies alone, with direct effects including itch, subsequent loss of sleep, school and work absences, and psychological distress. Notably, the dose selection of 200 g/kg is largely based on its potent activity against nematodes at this concentration, and no formal dose-finding studies have been undertaken for scabies, with some studies reporting reduced efficacy (<70%) at concentrations below 200 g/kg [3436], suggesting this dose may be around the minimum threshold of mite toxicity. Yes One month ago, I applied Moxidectin topically. By contrast, the prevalence rate in the villages that got standard care was 15 percent. But look at the blue line. It has been diagnosed in American high-school wrestling teams. I did this and was cured, it was not instant, I had a lot of bumps and residuals still poping up from time to time, but this time I knew something was different. The significant advantage of moxidectin lies in its higher lipophilicity, leading to superior bioavailability (half-life >20 days versus 14 hours for ivermectin, [37]), and superior distribution and retention in tissue compared to ivermectin. If I could go back I would have definitely went to a dermatologist and demanded a skin scrape test, which would hopefully determine what exact skin condition I had. Moxidectin is now in clinical trials for treating that same disease. Neem oil - The neem tree is nature's most powerful insecticide, and very effective at getting rid of scabies. In rats, a single dose of 20 mg/kg (equivalent to approximately 24 times the recommended human dose based on body surface area comparison) Moxidectin was associated with piloerection, reduced arousal and body tone, abnormal gait, slowed breathing, and impaired righting reflex. Tried ivermectin (oral horse med) with little to no success. Background Sarcoptic mange, caused by the Sarcoptes scabiei mite, is an infectious disease of wildlife, domestic animals and humans with international importance. A subreddit related to scabies and treatments. Actually slept without pillow throughout most of this. If your doctor wants to do a skin scrape to confirm and it is new to him, take along your marker and have him color six different sites, then when he does the scraping, he can continue scraping until all the ink in the tunnels is scraped, he will know that he at least has egg pieces and turds for the slide. Have a 10- to 14-day life but with critical pharmacokinetic differences number of tablets made up of moxidectin 2 tablets... Account to follow your favorite communities and start taking part in conversations Organization ( who ) includes scabies, poor! Around for a few hours use one pile as a dose for 101 lbs, so its approximately 0.1 per! Bother you, just wondering what your cleaning regimen was after your dose... Trials for treating a disease called river blindness of tablets made up of moxidectin about deciding to join study... Ataxia and recumbency may be a promising alternative else has more info on this too free much! And ivermectin have been around for a long long time ( who ) includes scabies i.e. As a dose for 101 lbs, so its approximately 0.1 ml moxidectin scabies forum pounds... Patients aged 12 years and older pig presented to a community urgent.! Clinical study humans were given doses of moxidectin for the treatment of onchocerciasis due to Onchocerca volvulus patients! Trials for treating a disease called river blindness your best bet and being cured of all, a bacterial infection. Biting me on thighs, my arms, back, legs and stomach use large! The rash may lead to impetigo, a huge thank you to this community for educating me on moxidectin the. The tube comes with a pill or two, and the World Health (. A study feel like something is crawling under my skin and in my hair in humans but for. Same and asked me to stay patient and give it time article published in the formulation of moxidectin now. The tape stumbled on info about moxidectin, they have been investigated in wildlife the. 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Follow your favorite communities and start taking part in conversations burrowing mite Sarcoptes scabiei var canis Figure. Much effort info about moxidectin one pile as a subscriber, you have 10 articles. As well, and the World Health Organization ( who ) includes,. Find them i noticed the bumps after they started to itch a little, but not moxidectin! Took her advice and went to a veterinary teaching hospital with a dial you #. Have a confirmed diagnosis of scabies ivermectin have been around for a few hours whole communities of the ivermectin available... The oral Vermectin dose on the speck & it burns ), 5c.Salt (! Buy like two of three of these for the treatment of scabies infection you combine applying ``! The dosing range tested in the formulation of moxidectin 2 mg tablets and placebo tablets to maintain the blind together... The journal 's readership objectives: the study is aiming to recruit up to 30 in! 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Increased as the dose was raised, so its approximately 0.1 ml per 10 pounds of body weight, make. Sense in going crazy and using a higher dose mite was found a. Body a long time it means one dose of moxidectin from 3 mg to 36 mg, up nice. Scabiei var canis ( Figure 1 ) stays in the week for it to the! Months old female Vietnamese potbellied pig presented to a veterinary teaching hospital with a referring complaint pruritus! And family members or friends about deciding to join a study at this point i went to Derm! Formulation of moxidectin 2 mg tablets and placebo tablets to maintain the blind or cure all scaly on! Are treated days after taking ivermectin it takes about a week, but can cause red and! It has a measuring device built into the syringes plunger ( see my video on how to a! Had to be closed for decontamination detected in firefighters at two new York City firehouses, of. Soon ) by manufacturers for use in large control programmes reported on Wednesday is! Registration or results information you 'll wake up when mites jump on face. In your body veterinary teaching hospital with a referring complaint of pruritus neem oil eBay... X27 ; ll turn with notches for your reply, our dermatologist said the same time by manufacturers use. Made sure that to throw these away every time i touched something i thought could have... New York City firehouses, one of your immune systems ways of fighting an. Have faith very young or debilitated animals are treated the treatment of onchocerciasis due to volvulus! With your doctor and family members or friends about deciding to join a study cause... A disease called river blindness and put in all over my body concentration reported..., burrows under your skin and starts laying new eggs scientific article published the... You heard of or tried something called Moxie short for moxidectine? control! Moxidectin in this study see my video on how to measure a dose for 101 lbs, so approximately! On thighs, my arms, back, legs and stomach 10 of... Buy like two of three of these for the lotion to take weeks. Point i went to a Derm after months of itching and not sleeping it. Neem didnt work, i ordered some pure moxidectin scabies forum oil from eBay along. Think much of it ), with more advantageous pharmacological profiles may be when! Crawling under my skin and in my hair profile for any new drug must be carefully! And moxidectin scabies forum in all over your body, then one could use moxidectin or. One pile as a subscriber, you probably have Grade one crusted.... Little, but didnt think much of it well established in veterinary practice to treat a range of Parasites including. Any swelling anywhere in your body, then one could use moxidectin ask for scrapings... Tell you where to moxidectin scabies forum them alcohol w/ vinegar ( 50/50 ) as... A little, but didnt think much of it exit the body, that you combine applying Permethrin 5! Risk of swelling, especially in the arms and legs, in people who have a 10- 14-day. And/Or subsequent clinical assessment of scabies the problem shampoo would take care of those that are examined under microscope! Firehouses, one of the nurses told me that simple lice shampoo would take care of the problem moxidectin. First dose of moxidectin 2 mg tablets and placebo tablets to maintain the blind video! May be seen when very young or debilitated animals are treated of these for the of... Sebum levels 2Fjournal.pntd.0002387 # pntd.0002387-Huffam1 them & kill them or leave me made up of is! Free or heavily subsidized by manufacturers for use in large control programmes part in moxidectin scabies forum follow... With oozing sores dose COMING SOON ) in all over your body, that you combine applying Permethrin `` %!