Use Caution/Monitor.Minor (1)flurbiprofen will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. rivastigmine increases toxicity of oxaprozin by pharmacodynamic synergism. It blocks the inflammatory process in your body, which relieves pain and swelling. Either increases toxicity of the other by pharmacodynamic synergism. oxaprozin and tolmetin both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. fenoprofen and oxaprozin both increase anticoagulation. Monitor Closely (2)pivmecillinam, oxaprozin. oxaprozin increases effects of chlorpropamide by unknown mechanism. Modify Therapy/Monitor Closely. Please confirm that you would like to log out of Medscape. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Monitor Closely (2)oxaprozin and piroxicam both increase anticoagulation. oxaprozin and tenecteplase both increase anticoagulation. Juvenile rheumatoid arthritis Osteoarthritis Rheumatoid arthritis Oxaprozin (Daypro) dosage forms tablet 600mg Typical dosing for oxaprozin (Daypro) Use Caution/Monitor. Use Caution/Monitor.oxaprozin decreases effects of acebutolol by pharmacodynamic antagonism. aspirin and oxaprozin both increase serum potassium. Check your blood pressure regularly and tell your doctor if the results are high.Tell your doctor right away if you have any serious side effects, including: headache that is severe or doesn't go away, vision changes, hearing changes (such as ringing in the ears), mental/mood changes, unexplained stiff neck, signs of kidney problems (such as change in the amount of urine), easy bruising/bleeding, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).This drug may rarely cause serious (possibly fatal) liver disease. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.meloxicam and oxaprozin both increase serum potassium. Use Caution/Monitor. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity. Monitor Closely (1)oxaprozin decreases effects of terazosin by pharmacodynamic antagonism. oxaprozin decreases effects of hydralazine by pharmacodynamic antagonism. unspecified interaction mechanism. Serious - Use Alternative (1)oxaprozin and apixaban both increase anticoagulation. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Minor (1)oxaprozin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by decreasing renal clearance. Use Caution/Monitor. oxaprozin and sulfasalazine both increase anticoagulation. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)metolazone will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. oxaprozin increases and metaproterenol decreases serum potassium. Use Caution/Monitor. Other (see comment). Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Long term (>1 wk) NSAID use. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, trandolapril. Use Caution/Monitor. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). oxaprozin and Siberian ginseng both increase anticoagulation. Monitor Closely (3)oxaprozin decreases effects of eprosartan by pharmacodynamic antagonism. oxaprozin and noni juice both increase serum potassium. Either increases levels of the other by decreasing renal clearance. Other (see comment). Minor (1)cefadroxil will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. View the formulary and any restrictions for each plan. Oxaprozin (Daypro) 600 mg three times daily: $26 ($225) Piroxicam (Feldene) 20 mg daily: $15 ($133) Salsalate: 750 mg twice daily: $14 (NA) Sulindac (Clinoril) 150 mg twice daily: $19 (NA) 200 mg . ticagrelor, oxaprozin. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Minor/Significance Unknown. Each drug may increase the photosensitizing effect of the other. Modify Therapy/Monitor Closely. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Either increases effects of the other by anticoagulation. Use Caution/Monitor.diflunisal and oxaprozin both increase serum potassium. Either increases toxicity of the other by Other (see comment). oxaprozin and agrimony both increase anticoagulation. oxaprozin, ketorolac. hydrochlorothiazide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Comment: May be associated with fluid and electrolyte imbalances. Use Caution/Monitor. Minor/Significance Unknown. oxaprozin, betrixaban. Use Caution/Monitor. Monitor Closely (1)oxaprozin will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. aspirin/citric acid/sodium bicarbonate and oxaprozin both increase anticoagulation. phenindione and oxaprozin both increase anticoagulation. Increased risk of upper GI bleeding. Use Caution/Monitor. Increased risk of upper GI bleeding. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)oxaprozin decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Use Caution/Monitor.oxaprozin decreases effects of metoprolol by pharmacodynamic antagonism. Monitor Closely (1)oxaprozin and dong quai both increase anticoagulation. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)oxaprozin increases effects of glipizide by unknown mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor.oxaprozin and tolfenamic acid both increase serum potassium. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor. pharmacodynamic antagonism. Canada residents can call a provincial poison control center. Minor/Significance Unknown. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. oxaprozin and anamu both increase anticoagulation. Which pain reliever and what drug formulation is the best choice at any given time depends on the type of pain being treated, whether it is acute or chronic, the treatment setting (hospital vs. community), and any other diseases you have and medications you take because there can be unwanted interactions. Use Caution/Monitor. Monitor Closely (1)amiloride and oxaprozin both increase serum potassium. Monitor Closely (1)oxaprozin decreases effects of moxisylyte by pharmacodynamic antagonism. metoprolol and oxaprozin both increase serum potassium. Avoid or Use Alternate Drug. Long term (>1 wk) NSAID use. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. perindopril, oxaprozin. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Minor/Significance Unknown. Defibrotide may enhance effects of platelet inhibitors. labetalol and oxaprozin both increase serum potassium. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Therapeutic duplicationibuprofen and oxaprozin both increase serum potassium. oxaprozin increases and albuterol decreases serum potassium. Other (see comment). Effect of interaction is not clear, use caution. indapamide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Do not store in the bathroom. Use Caution/Monitor. Monitor Closely (2)ketoprofen and oxaprozin both increase anticoagulation. antiplatelet effects. Either increases toxicity of the other by pharmacodynamic synergism. oxaprozin, hydrocortisone. Use Caution/Monitor. Increased risk of upper GI bleeding. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ramipril, oxaprozin. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. serotonin uptake by platelets. cephalexin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)oxaprozin, methylprednisolone. Increased risk of GI ulceration. Monitor Closely (1)latanoprost, oxaprozin. Therapeutic duplication ibuprofen IV and oxaprozin both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, lisinopril. Caution is advised, both drugs have the potential to cause bleeding. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. oxaprozin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)oxaprozin and potassium citrate both increase serum potassium. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, oxaprozin. This drug is available at a higher level co-pay. Use Caution/Monitor. elvitegravir/cobicistat/emtricitabine/tenofovir DF, sodium picosulfate/magnesium oxide/anhydrous citric acid, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, triamcinolone acetonide injectable suspension, NSAIDs may increase risk of serious cardiovascular thrombotic events, myocardial infarction (MI), & stroke, which can be fatal, Patients with risk factors for or existing cardiovascular disease may be at greater risk, NSAIDs are contraindicated for perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (increased risk of MI & stroke), NSAIDs increase risk of serious GI adverse events including bleeding, ulceration, & perforation of the stomach or intestines, which can be fatal, GI adverse events may occur at any time during use & without warning symptoms, Elderly patients are at greater risk for serious GI events, NSAIDS have the potential to trigger HF by prostaglandin inhibition that leads to sodium and water retention, increased systemic vascular resistance, and blunted response to diuretics, NSAIDS should be avoided or withdrawn whenever possible, AHA/ACC Heart Failure Guidelines; Circulation. pharmacodynamic antagonism. Monitor Closely (1)oxaprozin and potassium chloride both increase serum potassium. sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of oxaprozin by Other (see comment). pharmacodynamic antagonism. Mechanism: Displacement of GABA from receptors in brain. oxaprozin, cyclosporine. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin. losartan and oxaprozin both increase serum potassium. Minor/Significance Unknown. Monitor Closely (1)oxaprozin, budesonide. Use Caution/Monitor.Minor (1)oxaprozin will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. serotonin uptake by platelets. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Modify Therapy/Monitor Closely. People with chronic neuropathic pain and fibromyalgia reported small short-term improvements in pain and function with certain anticonvulsants and moderate short-term improvement with certain antidepressants. Therapeutic duplication ibuprofen and oxaprozin both increase serum potassium. oxaprozin decreases effects of azilsartan by pharmacodynamic antagonism. Use Caution/Monitor. tobramycin inhaled and oxaprozin both increase nephrotoxicity and/or ototoxicity. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF, oxaprozin. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. sotalol and oxaprozin both increase serum potassium. NSAIDs decrease prostaglandin synthesis. Monitor Closely (1)oxaprozin and ginkgo biloba both increase anticoagulation. Monitor Closely (1)oxaprozin, zanubrutinib. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, moexipril. Comment: Combination may increase GI bleeding, ulceration and irritation. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)oxaprozin will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Long term (>1 wk) NSAID use. Monitor Closely (1)clomipramine, oxaprozin. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Daypro is a trading name for the parent Medicine Oxaprozin or Oxaprozinum. Modify Therapy/Monitor Closely. Minor/Significance Unknown. oxaprozin decreases effects of candesartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Our phase IV clinical studies alone cannot establish cause-effect relationship. metolazone will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by anticoagulation. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. If you take either of these OTC NSAIDs, there's a small chance your urine test may be positive for barbiturates (a type of sedative) or THC. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)oxaprozin increases levels of pralatrexate by decreasing renal clearance. oxaprozin decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Effect of interaction is not clear, use caution. nebivolol and oxaprozin both increase serum potassium. Monitor Closely (2)nabumetone and oxaprozin both increase anticoagulation. meclofenamate and oxaprozin both increase serum potassium. unspecified interaction mechanism. Either increases effects of the other by anticoagulation. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. GI mucosal injury/bleeding risk. Increased risk of upper GI bleeding. Meloxicam is a generic NSAID medication that can treat inflammation, pain, and swelling from arthritis. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Either increases toxicity of the other by Other (see comment). Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Other (see comment). Minor/Significance Unknown. Monitor Closely (1)oxaprozin and alteplase both increase anticoagulation. oxaprozin, quinapril. Monitor Closely (1)oxaprozin, vorapaxar. oxaprozin, lisinopril. 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